Nobuhiro Nishiyama Selected Research

DEET (DET)

1/2022	Changeable net charge on nanoparticles facilitates intratumor accumulation and penetration.
1/2018	An Ethylenediamine-based Switch to Render the Polyzwitterion Cationic at Tumorous pH for Effective Tumor Accumulation of Coated Nanomaterials.
6/2012	Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination.
12/2011	Gene transfer using micellar nanovectors inhibits corneal neovascularization in vivo.
7/2009	Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats.

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Nobuhiro Nishiyama Research Topics

Disease

95	Neoplasms (Cancer) 01/2022 - 01/2003
15	Atrial Fibrillation 12/2020 - 07/2013
11	Pancreatic Neoplasms (Pancreatic Cancer) 01/2019 - 12/2009
11	Neoplasm Metastasis (Metastasis) 12/2018 - 03/2003
6	Colonic Neoplasms (Colon Cancer) 10/2017 - 01/2005
5	Hypoxia (Hypoxemia) 01/2021 - 07/2008
5	Adenocarcinoma 01/2011 - 02/2007
4	Hearing Loss (Hearing Impairment) 01/2021 - 04/2010
4	Hepatocellular Carcinoma (Hepatoma) 01/2019 - 02/2005
4	Uterine Cervical Neoplasms (Cancer of the Cervix) 10/2016 - 09/2014
4	Carcinoma (Carcinomatosis) 06/2016 - 11/2003
3	Glioblastoma (Glioblastoma Multiforme) 07/2016 - 10/2013
3	Lung Neoplasms (Lung Cancer) 06/2016 - 02/2014
3	Paroxysmal ventricular fibrillation 11/2015 - 01/2013
3	Fibrosis (Cirrhosis) 11/2015 - 02/2007
3	Ventricular Fibrillation 10/2013 - 01/2013
3	Myocardial Infarction 09/2012 - 05/2010
3	Corneal Neovascularization 12/2011 - 11/2005
2	Breast Neoplasms (Breast Cancer) 12/2018 - 07/2017
2	Hemorrhage 12/2018 - 10/2010
2	Pulmonary Arterial Hypertension 01/2018 - 10/2017
2	Hypertension (High Blood Pressure) 01/2018 - 07/2015
2	Squamous Cell Carcinoma of Head and Neck 10/2017 - 01/2002
2	Lymphatic Metastasis 12/2015 - 05/2015
2	Brugada Syndrome 11/2015 - 10/2013
2	Stomach Neoplasms (Stomach Cancer) 11/2015 - 02/2007
2	Stroke (Strokes) 07/2015 - 06/2013
2	Heart Failure 07/2015 - 07/2007
2	Body Weight (Weight, Body) 06/2015 - 12/2003
2	Melanoma (Melanoma, Malignant) 05/2015 - 10/2013

Drug/Important Bio-Agent (IBA)

54	MicellesIBA 01/2019 - 12/2003
22	Pharmaceutical PreparationsIBA 10/2021 - 12/2003
16	PolymersIBA 11/2021 - 12/2003
15	Ethylene Glycol (Monoethylene Glycol)IBA 01/2022 - 12/2003
15	Small Interfering RNA (siRNA)IBA 07/2017 - 02/2005
12	1-phenyl-3,3-dimethyltriazene (PDT)IBA 12/2020 - 01/2003
10	PlatinumIBA 01/2016 - 01/2005
9	cyclic arginine-glycine-aspartic acid peptideIBA 01/2018 - 09/2007
8	Peptides (Polypeptides)IBA 01/2021 - 09/2007
8	LigandsIBA 10/2017 - 07/2007
7	Therapeutic UsesIBA 12/2021 - 09/2007
7	calcium phosphateIBA 07/2017 - 08/2012
7	Photosensitizing Agents (Photosensitizers)IBA 05/2016 - 12/2003
6	DNA (Deoxyribonucleic Acid)IBA 12/2021 - 12/2008
6	Lysine (L-Lysine)FDA Link 10/2021 - 02/2005
6	Proteins (Proteins, Gene)FDA Link 01/2017 - 12/2008
6	Contrast MediaIBA 01/2016 - 12/2009
5	DEET (DET)IBA 01/2022 - 07/2009
5	IntegrinsIBA 01/2018 - 03/2003
5	Cisplatin (Platino)FDA LinkGeneric 10/2017 - 12/2003
5	Drug CarriersIBA 07/2016 - 01/2005
5	GadoliniumIBA 04/2016 - 09/2010
5	PAsp(DET)IBA 01/2016 - 12/2008
5	DisulfidesIBA 09/2014 - 04/2010
5	Oxaliplatin (Eloxatin)FDA LinkGeneric 10/2013 - 01/2005
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2012 - 07/2008
4	Messenger RNA (mRNA)IBA 06/2016 - 04/2010
4	Gadolinium DTPA (Magnevist)FDA Link 04/2016 - 01/2013
4	AcidsIBA 01/2014 - 02/2005
3	GoldIBA 01/2022 - 09/2010
3	ethylenediamine (ethylenediamine dihydroiodide)FDA Link 01/2022 - 12/2008
3	IronIBA 12/2021 - 12/2009
3	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2018 - 06/2013
3	Glutamic Acid (Glutamate)FDA Link 01/2017 - 12/2003
3	EnzymesIBA 01/2016 - 12/2008
3	ferric oxide (iron oxide)IBA 06/2015 - 09/2010
3	LuciferasesIBA 09/2014 - 07/2013
3	4-S-(propionic acid)sulfidocyclophosphamide (PASP)IBA 02/2014 - 12/2008
3	MetalsIBA 01/2013 - 12/2003
3	polyethylene glycol-block-polyaspartic acidIBA 06/2012 - 12/2003
3	Dendrimers (Dendrons)IBA 02/2009 - 12/2003
2	Chelating AgentsIBA 12/2021 - 01/2021
2	benzeneboronic acidIBA 11/2021 - 10/2013
2	Amino Acid Transport Systems (Amino Acid Transporter)IBA 10/2021 - 01/2020
2	BoronIBA 10/2021 - 01/2017
2	FructoseIBA 10/2021 - 01/2020
2	4-boronophenylalanineIBA 10/2021 - 01/2020
2	SolutionsIBA 01/2020 - 01/2013
2	EstersIBA 01/2020 - 02/2009
2	RivaroxabanIBA 12/2018 - 01/2017
2	Dihydrotachysterol (AT 10)IBA 12/2018 - 03/2008
2	Warfarin (Coumadin)FDA LinkGeneric 12/2018 - 01/2017
2	arginyl-glycyl-aspartic acidIBA 10/2017 - 10/2013
2	Transcription Factors (Transcription Factor)IBA 01/2017 - 03/2013
2	MicroRNAs (MicroRNA)IBA 01/2017 - 01/2015
2	Biological ProductsIBA 01/2017 - 01/2005
2	Coloring Agents (Dyes)IBA 10/2016 - 09/2005
2	Indicators and Reagents (Reagents)IBA 06/2015 - 07/2010
2	Liposomes (Liposome)IBA 05/2015 - 12/2006

Therapy/Procedure

42	Therapeutics 12/2021 - 12/2003
15	Catheter Ablation 12/2020 - 01/2013
10	Photochemotherapy (Photodynamic Therapy) 05/2016 - 01/2003
6	Lasers (Laser) 02/2016 - 03/2008
5	Intravenous Injections 10/2016 - 09/2010
3	Boron Neutron Capture Therapy 10/2021 - 01/2017
3	Radiotherapy 01/2021 - 01/2002
3	Neutron Capture Therapy 04/2016 - 06/2015
2	Denervation 01/2018 - 10/2017
2	Drug Therapy (Chemotherapy) 01/2016 - 10/2013
2	Defibrillators (Defibrillator) 12/2015 - 01/2013